Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 51940-64-8, name is Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate. A new synthetic method of this compound is introduced below., category: pyrimidines
a) (S)-Ethyl 2-chloro-4-(1 -(5-fluoropyridin-2-yl)ethylamino)pyrimidine-5- carboxylateA solution of ethyl 2,4-dichloropyrimidine-5-carboxylate (prepared as described in WO2009/131687, 0.29 g, 1.31 mmol), (S)-1 -(5-fluoropyridin-2-yl)ethanamine hydrochloride (prepared as described in WO2006/1231 13, 0.28 g, 1.59 mmol) and diisopropylethylamine (0.69 ml_, 3.96 mmol) in acetonitrile (3 mL) was stirred overnight at ambient temperature. Water was then added and the reaction mixture was extracted with diethyl ether. The organic phase was washed with water and brine, dried (MgS04), filtered and the solvents evaporated under reduced pressure to yield the title compound (0.49 g, 85%) as an oil.LRMS (m/z): 325 (M+1 )+.1H-NMR delta (CDCIs): 1 .41 (t, 3H), 1 .58 (d, 3H), 4.39 (q, 2H), 5.42-5.55 (m, 1 H),7.31 (dd, 1 H), 7.39 (dd, 1 H), 8.49 (d, 1 H), 8.69 (s, 1 H), 9.37 (d, 1 H
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Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; BACH TANA, Jordi; PAGES SANTACANA, Lluis Miquel; WO2013/17461; (2013); A1;,
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