Electric Literature of 55150-17-9 ,Some common heterocyclic compound, 55150-17-9, molecular formula is C6H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(2) 2,2,2-Trichloroethyl (4-ethoxyprimidin-5-yl)carbamate; To a solution of 4-ethoxypyrimidine-5-amine (1.00 g, 7.19 mmol) and pyridine (1.74 ml, 21.6 mmol) in tetrahydrofuran (20 ml) was added 2,2,2-trichloroethyl chloroformate (1.49 ml, 10.8 mmol) with ice-cooling, the mixture was stirred for 30 minutes with ice-cooling, the reaction mixture was poured into ice-water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of ethyl acetate and hexane to obtain the desired product (1.73 g, 76.5%) as a solid. 1H-NMR (CDCl3) delta; 1.48 (3H, t, J = 7.2 Hz), 4.55 (2H, q, J = 7.2 Hz), 4.87 (2H, s), 7.15(1H, br s), 8.51 (1H, s), 9.20 (1H, br s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55150-17-9, 4-Ethoxypyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia