611-08-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 611-08-5, name is 5-Nitrouracil, molecular formula is C4H3N3O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 2′,3′,5′-tri-O-Benzoyl-5-fluorouridine (3a)S1 (Table 2, entry 1). A mixture of5-fluorouracil (51.1 mg, 0.39 mmol), pyridine (0.6 mL), and hexamethyldisilazane(HMDS) (1.2 mL) was refluxed for ca. 40 min to give a clear solution of 2a. All thevolatiles were then removed under reduced pressure (ca. 1 mmHg) to give a clear syrup,which was dissolved in acetone (3.0 mL). To this were added1-O-acetyl-2,3,5-tri-O-benzoyl–D-ribofuranose (1) (151.8 mg, 0.30 mmol) and 7b (4.5mg, 0.015 mmol, 5 mol%) and the mixture was stirred under reflux for 6 h. After themixture was cooled to rt, it was diluted with EtOAc (2 mL), followed by the addition ofa saturated NaHCO3 aq (2 mL) at 0 C. After the mixture was stirred at 0 oC for 15min, EtOAc (30 mL) and a saturated NaHCO3 aq (20 mL) were added. The organicphase was separated and the aqueous phase was back-extracted with EtOAc (30 mL x 3).The combined organic layers were dried with Na2SO4 and evaporated to afford a crudematerial, which was purified by recrystallization from EtOAc (5 mL) and hexane (7mL) to afford 2′,3′,5′-tri-O-benzoyl-5-fluorouridine (3a) (152 mg, 88%) as a whitepowder.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 611-08-5, 5-Nitrouracil, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Shirouzu, Hiroshi; Morita, Hiroki; Tsukamoto, Masaki; Tetrahedron; vol. 70; 22; (2014); p. 3635 – 3639;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia