In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63558-65-6, name is 4-Chloro-5-iodopyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 4-Chloro-5-iodopyrimidine
Step 3: N-4′-[(5-Iodopyrimidin-4-yl)amino]-6-methylbiphenyl-3-yl-3-(trifluoromethyl)benzamideTo lambda^-(4′-amino-6-methylbiphenyl-3-yl)-3-(trifluoromethyl)benzamide (60.0 mg, 0.162 mmol) was added 4-chloro-5-iodopyrimidine (39 mg, 0.16 mmol) followed by ethanol (0.47 mL). The reaction was heated to 80 0C in a sealed tube until LCMS indicated complete reaction, typically 1 -2 hours. The reaction was cooled to ambient temperature and the solvent was evaporated. The residue was partitioned between saturated aqueous NaHCO3 and EtOAc, the organic phase was washed with brine, dried (MgSO4) and evaporated to leave the crude product, which was then purified by column chromatography to give the final compound (39.9 mg, 42.88%). 1H NMR (400 MHz, CDCl3): delta 8.61 (s, 2H), 8.14 (s, IH), 8.08 (d, IH), 7.95 (s, IH), 7.81 (d, IH), 7.5-7.7 (m, 5H), 7.40 (m, 3H), 7.29 (d, IH), 2.29 (s, 3H). MS (EI) m/z = 575 (M+H).
The synthetic route of 63558-65-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INCYTE CORPORATION; WO2008/79965; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia