Related Products of 705263-10-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 705263-10-1, name is 6-Bromopyrazolo[1,5-a]pyrimidine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a muwave vial, 6-bromopyrazolo[1,5-a]pyrimidine, 9, (0.25 g, 1.26 mmol, 1.0 eq), 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine, 10, (0.36 g, 1.26 mmol, 1.0 eq), and Pd(dppf)Cl2?DCM (52.0 mg, 0.06 mmol, 0.05 eq) were added. The muwave vial was evacuated under reduced pressure and purged with Argon (3x). To the mixture was added 1,4-dioxane (9 mL), followed by a solution of K3PO4 (0.54 g, 2.52 mmol, 2.0 eq) in H2O (4.0 mL). The reaction was heated to 150 C for 30 min under microwave irradiation. The reaction was added to EtOAc: H2O (1:1, 100 mL). The organic layer was separated, washed with H2O (25 mL), Brine (25 mL), dried (MgSO4), filtered and concentrated. The material was purified by reverse-phase HPLC (5-35% acetonitrile: H2O w/ 0.1% TFA) to afford 4-(4-(pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)morpholine, 11 (0.25 g, 71% yield).LCMS: RT = 0.560 min, >98% (at) 215 and 254 nM, m/z = 281.1 [M + H]+.
According to the analysis of related databases, 705263-10-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Engers, Darren W.; Frist, Audrey Y.; Lindsley, Craig W.; Hong, Charles C.; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3248 – 3252;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia