Application of 7752-78-5, Adding some certain compound to certain chemical reactions, such as: 7752-78-5, name is 5-Bromo-2-methylpyrimidine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7752-78-5.
To the above mixture, 5-bromo-2-methylpyrimidine (75.7 mg, 0.44 mmol) was added followed by water (1 mL) and K2C03 (110.4 mg, 0.80 mmol), and the mixture was degassed under N2 three times. Pd(PPh3)4 (46.2 mg, 0.04 mmol) was added, and the resulting mixture was stirred at 95 °C under N2 atmosphere for 16 hours. The reaction mixture was concentrated to dryness and diluted with EtOAc, washed with water and brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by column chromatography on silica gel (PE: EtOAc= 2: 1) to give compound 44S-13 (110 mg, 62.9percent yield) as a white solid. LC/MS (ESI) m/z: 437 (M+H)t
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7752-78-5, 5-Bromo-2-methylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; CHEN, Dawei; GADHACHANDA, Venkat, Rao; BARRISH, Joel, Charles; AGARWAL, Atul; EASTMAN, Kyle, J.; (0 pag.)WO2018/160892; (2018); A1;,
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