Related Products of 830346-47-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 830346-47-9 as follows.
Bromine (16.5 mL, 0.32 mmol) was added to 1- [2-FLUORO-6- (trifluoromethyl) benzyl]-6-methylpyrimidine-2, 4 (1H, 3H)-dione lc (48.5 g, 0.16 mol) in 145 mL of acetic acid. The resulting mixture became clear then formed precipitate within an hour. After 2 hours stirring, the yellow solid was filtered and washed with cold EtOAc to an almost white solid. The filtrate was washed with sat. NAHC03 and dried over NA2S04. Evaporation gave a yellow solid which was washed with ETOAC to give a light yellow solid. The two solids were combined to give 59.4 g of LD (0.156 mol) total NMR (CDC13) 8 2.4 (s, 3H), 5.48 (s, 2H), 7.25-7. 58 (M, 3H), 8.61 (s, 1H) ; MS (CI) m/z 380.9 (MH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,830346-47-9, its application will become more common.
Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/7165; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia