Synthetic Route of 85979-59-5, Adding some certain compound to certain chemical reactions, such as: 85979-59-5, name is 2-Chloro-4-(4-fluoro-phenyl)-pyrimidine,molecular formula is C10H6ClFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85979-59-5.
To a solution of 68 (109 mg, 0.25 mmol) and 2-chloro-4-phenylpyrimidine (77 mg,0.37 mmol) in t-BuOH (3 mL) was added conc. HCI (0.25 mL). The reaction was heatedat 80 C for 8 hours before concentrated under reduced pressure. The residue was dissolved in CH3CN and basified with Et3N. The resulting solution was purified by reverse prep-HPLC and then silica gel prep-TLC to give 3-((4-(4-fluorophenyl)pyrimidin- 2-yl)amino)-4-methyl-N-(3-(4-methyl-1 H-imidazol-1 -yl)-5-(4-methylpiperazin-1 -yl)phenyl)benzenesulfonamide (21 mg, 14%) as an off-white solid.
According to the analysis of related databases, 85979-59-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia