Electric Literature of 89581-38-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 89581-38-4 as follows.
To the reaction flask was added 1 mmol of compound F18,2 mmol Cs2CO3,1 ml of DMF and 2 mmol of 5-bromo-2-pyrimidinecarboxylic acid methyl ester. The reaction mixture was heated to 80 C for 2 h under nitrogen. After the reaction was complete, water was added. The organic phase was extracted with ethyl acetate, dried over anhydrous sodium sulfate, The filtrate was concentrated under reduced pressure and then purified using a silica gel column (petroleum ether: ethyl acetate = 1: 1 as eluent) to give the title product as a pale yellow oily liquid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89581-38-4, its application will become more common.
Reference:
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Chen, Lijuan; Long, Chaofeng; Chen, Xiaoxin; Liu, Zhuowei; Ye, Haoyu; Xie, Chengshi; (104 pag.)CN106045923; (2016); A;,
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