Application of 98138-75-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 98138-75-1 as follows.
To 6-chloro-4-methoxy-1 H-pyrazolo[3,4-d]pyrimidine (2.45 g) dissolved in dry DMF (60 ml) was added N-iodosuccinimide (3.45 g) and the reaction mixture heated to 80C under stirring. After 3 h the reaction mixture was cooled to RT and the DMF removed by rotary evaporation. Water was added to the residue which was then extracted three times with tert-butyl methyl ether. The combined organic phases were washed with water and brine and dried over sodium sulfate, filtered and evaporated to afford 6-chloro-3-iodo-4-methoxy-1 H-pyrazolo[3,4-d]pyrinnidine as a brown solid. Yield: 4.13 g (100%). MS (ES+): m/e = 310.9 (M+H), chloro pattern
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98138-75-1, its application will become more common.
Reference:
Patent; SANOFI; NAZARE, Marc; HALLAND, Nis; SCHMIDT, Friedemann; KLEEMANN, Heinz-Werner; WEISS, Tilo; SAAS, Joachim; STRUEBING, Carsten; WO2014/140065; (2014); A1;,
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