In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99586-66-0, name is 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. Quality Control of 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile
d) 2-Am ino-4-((2S,4S)-4-hydroxy-2-(4-oxo-3-phenyl-5-(trifluoromethyl)-3,4- dihydroquinazolin-2-yI)pyrrolidin-1 -yI)-6-methylpyrimidine-5-carbonitrile A solution of 2-((2S,4S)-4-hydroxypyrrolidin-2-yl)-3-phenyl-5-trifluoromethyl)qu inazolin-4(3H)-one (290 mg, 0.77 mmol) and 2-amino-4-chloro-6-methylpyrimidine-5-carbonitrile (CAS registry 99586-66-0) (130 mg, 0.77 mmol) in nBuOH (7.7 ml) was treated with DIPEA (0.540 ml, 3.09 mmol) and was stirred at 90C for 18 h in an oil bath. The reaction mixture was cooled down, and evaporated under reduced pressure. The oil was taken up in DCM and washed with water, the organic layer was dried over MgSO4 and concentrated in vacuo (500mg). The crude was purified over SFC (column NH2, 250 x 30 mm, 60A, 5pm, Princeton, flow at 100 mI/mm; gradient of MeCH in supercritical CC2, from 17% to 22% in ii mm) and triturated with pentane to afford the title compound as a beige solid (258 mg, 66% yield).HPLC RtM2=0.94 mm; ESIMS: 508 [(M+H)].1H NMR (400 MHz, DMSO-d6): O 7.98 – 7.80 (m, 4H), 7.65-7.47 (m, 4H), 7.13-6.52 (m, 2H),5.25 (brs, 1H), 4.65 (brs, 1H), 4.17 (d, 2H), 3.79-3.60 (m, 1H), 2.27 (5, 3H), 2.07-1.96 (m,1H), 1.96-1.84 (m, 1H).
The synthetic route of 99586-66-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; GUIBOURDENCHE, Christel; HINTERMANN, Samuel; HURTH, Konstanze; JACQUIER, Sebastien; KALIS, Christoph; MOEBITZ, Henrik; SOLDERMANN, Nicolas; WO2014/128612; (2014); A1;,
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