Synthetic Route of 876343-10-1, Adding some certain compound to certain chemical reactions, such as: 876343-10-1, name is 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H3ClIN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 876343-10-1.
A mixture of 4-chloro-6-iodo- 7/-/-pyrrolo[2,3-c]pyrimidine (400 mg, 1.43 mmol), phenylboronic acid (524 mg, 4.29 mmol), copper(ll) acetate (520 mg, 2.86 mmol) and 1 , 10-phenanthroline (516 mg, 2.86 mmol) in anhydrous dimethylformamide (16 mL) was stirred for 16 h. The reaction mixture was partitioned between saturated ammonium chloride (80 mL), water (80 mL) and ethyl acetate (80 mL). The separated aqueous phase was extracted with ethyl acetate (3 x 80 mL). The combined organic phase was washed with 1 : 1 brine/water (4 x 80 mL), dried (Na2S04), filtered, and concentrated in vacuo. The residue was purified by flash chromatography (0- 30% EtOAc in cyclohexane) to afford the title compound (207 mg, 41 %). LCMS (Method B): RT = 1.42 min, m/z = 356 [M+H]+.
According to the analysis of related databases, 876343-10-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin; HARRISON, Tim; HEWITT, Peter; ROUNTREE, Shane; HUGUES, Miel; BURKAMP, Frank; JORDAN, Linda; HELM, Matthew; BROCCATELLI, Fabio; CRAWFORD, James John; GAZZARD, Lewis; WERTZ, Ingrid; LEE, Wendy; (304 pag.)WO2018/73602; (2018); A1;,
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