On March 5, 1980, Ishikawa, Fumiyoshi; Ashida, Shinichiro published a patent.Category: pyrimidines The title of the patent was 1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones and pharmaceutical compositions containing them. And the patent contained the following:
The title compounds I (R, R1 = H, alkyl, Ph, Cl; RR1 = C3-5 alkylene; R2 = H, alkyl) and some isomers in the thiophene ring were prepared Thus 2,4-dichloro-5,6-dimethylthieno[2,3-d]pyrimidine was hydrogenated and cyclized with BrCH2CO2Et to give I (R = R1 = Me, R2 = H, II). II had blood platelet aggregation-inhibiting activity of 84% at 50 mg/kg orally in rats and caused 5 ± 3% decrease in blood pressure at the same dose. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Category: pyrimidines
The Article related to imidazothienopyrimidinone, platelet aggregation inhibitor imidazothienopyrimidinone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia