Jakubiec, Dominika; Przypis, Lukasz; Suwinski, Jerzy W.; Walczak, Krzysztof Z. published an article in 2017, the title of the article was Synthesis of 5-hetaryluracil derivatives via 1,3-dipolar cycloaddition reaction.Synthetic Route of 4433-40-3 And the article contains the following content:
1,3-Dipolar cycloaddition was applied for the synthesis 5-hetaryluracil derivatives where substituted uracils played the role of 1,3-dipoles or dipolarophiles. Treatment of the nitrile oxide derived from 5-formyluracil and substituted alkenes gave the appropriate 5-(4,5-dihydroisoxazol-3-yl)pyrimidine-2,4(1H,3H)-diones, which by oxidation with N-bromosuccinimide were transformed into appropriate 5-(isoxazol-3-yl)uracils. When 5-cyanouracil was used as a dipolarophile in the reaction with nitrile oxides, generated from aromatic aldoximes, several 5-(1,2,4-oxadiazol-5-yl)uracils were obtained. An alternative reaction of 5-formyluracil with an excess of nitriles in the presence of cerium ammonium nitrate as an oxidant gave 1,2,4-oxadiazol-3-yl derivatives in moderate yields. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Synthetic Route of 4433-40-3
The Article related to dioxopyrimidinyl aldoxime preparation alkene regioselective dipolar cycloaddition, dihydroisoxazolyl uracil preparation, nitrile dioxopyrimidinyl aldoxime dipolar cycloaddition, oxadiazoyl uracil preparation, phenyl aldoxime cyanouracil dipolar cycloaddition and other aspects.Synthetic Route of 4433-40-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia