Jat, Bhagchand; Santra, Swapna; Santra, Prasanta Kumar published the artcile< Synthesis and evaluation of antimicrobial activity of pyrimidine derivatives>, Formula: C6H2Cl2N2S, the main research area is pyridinylpropylphenylamino fused pyrimidine preparation antibacterial agrochem antifungal activity.
Synthesis, characterization and evaluation of antimicrobial activity of novel pyrimidine derivatives containing O, N, and S in the ring was reported. Pyrimidine derivatives were prepared in three steps. In the first step, chalcones containing -NO2 functional group were synthesized using Claisen-Schmidt condensation of aromatic aldehydes with 2-acetyl pyridine/3-acetylpyridine in methanol in the presence of aqueous NaOH. In the second step, -NO2 group was reduced to -NH2 group. Resulting compounds containing -NH2 functional group were reacted with different dichlorothienopyrimidines and dichlorofuropyrimidines in the presence of N,N-diisopropylethylamine to obtain pyrimidine derivatives Antibacterial and antifungal activity of pyrimidine derivatives were studied in-vitro. Antibacterial and antifungal activity of the newly synthesized pyrimidine derivatives will definitely inspire future researchers for the preparation of new analogs.
Asian Journal of Pharmaceutical and Clinical Research published new progress about Agrochemical fungicides. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Formula: C6H2Cl2N2S.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia