Relation between goitrogenic effect and chemical constitution was written by Jensen, K. A.;Kjerulf-Jensen, K.. And the article was included in Acta Pharmacologica et Toxicologica in 1945.Name: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one The following contents are mentioned in the article:
In young rats, benzenesulfonic acid, phenyl p-toluenesulfonate, p-toluenesulfonamide, taurine, N4-(o-carboxybenzoyl)sulfathiazole, Na salt of N4-(1-sulfoethyl)sulfathiazole, p-tolyl isothiocyanate, ethylene dithiocyanate, mercaptoacetic acid, cysteine, mercaptosuccinic acid, p-toluenethiol, o-mercaptobenzoic acid, dibenzyl sulfide, bis(2-carboxyethyl) sulfide, α,α’-(thiocarbonyldithio)bis[glycolic acid], thioacetamide, thiobenzamide, xanthogenamide (H2NC(:S)OEt), Et thionocarbanilate, N-allyl-N’-(m-carboxyphenyl)thiourea, selenourea, 2-methyl-2-thiopseudourea sulfate, thiosemicarbazide, 4-allylthiosemicarbazide, hydrazodithiodicarboxamide, 1,3-oxalylthiourea (thioparabanic acid), 1,3-ethylenethiocarbamide (2-thioxoimidazolidine), 2(3)-benzimidazolethione, 2-imino-4-thiazolidone-5-acetic acid, 5-imino-3-thioxo-1,2,4-dithiazolidine, 2-aminothiazole, thioammeline, 2-amino-4-methyl-6-mercaptopyrimidine, 6-methyl-4-thiouracil, 5-methyl-2-thiouracil (thiothymine), 6-methyluracil, 6-amino-2-thiouracil, 2-amino-4-hydroxy-6-methylpyrimidine, 2-mercapto-4-methyl-6-aminopyrimidine, 2-mercapto-4,6-dimethylpyrimidine, 2-methylmercapto-4-mercapto-6-methylpyrimidine, 2-mercapto-4-phenyl-6-methylpyrimidine, compound (1:1) of NH3 and 6-imino-5-isonitroso-2-thiouracil, 2-thio-5-aminobarbituric acid (thiouramil), 2-thio-5-ethylbarbituric acid, 2-thioxanthine, 2-thiopseudouric acid, dithiohydurilic acid, 2,4-dioxothiazolidine, 1,4-dithiane, s-trithiane, phenothiazine, biuret, biguanide, dicyandiamidine, thiodicyandiamidine, 1-phenylsemicarbazide, benzoylacetone, salicylaldehyde oxime, β-isatin oxime, dimethylglyoxime, 5-isonitrosobarbituric (violuric) acid, 1-phenyl-3-methyl-4-isonitroso-5-pyrazolone, salicylaldehyde phenylhydrazone, glyoxal osazone, 8-hydroxyquinoline, triphenylphosphine, triphenylarsine, K xanthate, Na diethyldithiocarbamate, KCN, Na2S, and Na2S2O3 had no goitrogenic action. Sulfaguanidine, sulfonal, dithioöxamide, thiourea, allylthiourea, 1,3-diphenylthiourea, 2-thiohydantoin, 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline, 1,3-(1,8-naphthylene)thiourea, thioantipyrine, and p-aminobenzoic acid were weakly goitrogenic or of doubtful effect. Methylthiourea, trimethylthiourea, tetramethylthiourea, dithizone, 6-methyl-2-thiouracil, 6-methyl-5-ethyl-2-thiouracil, 6-methyl-5-butyl-2-thiouracil (m. 189°, preparation described), 6-methyl-5-isoamyl-2-thiouracil (m. 222-3°, preparation given), and 4-phenyl-2-thiouracil were strongly goitrogenic. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Name: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one).
5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Name: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia