The N6-methylandenosine-related gene BIRC5 as a prognostic biomarker correlated with cell migration and immune cell infiltrates in low grade glioma was written by Jiang, Xiulin;Shi, Yulin;Chen, Xi;Xu, Haitao;Huang, Xiaobin;Li, Lihua;Pu, Jun. And the article was included in Frontiers in Molecular Biosciences in 2022.Related Products of 1373423-53-0 The following contents are mentioned in the article:
Gliomas account for 75% of all primary malignant brain tumors in adults and are associated with high mortality. Emerging evidence has demonstrated that baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5) plays a critical role in cell apoptosis and the progression of diverse cancers. However, no studies have yet focused on the immunol. function and mechanisms of upstream BIRC5 regulation in the progression of low-grade gliomas (LGG). Here, author evaluated BIRC5 expression and clin. characteristics in people with LGG using the Chinese Glioma Genome Atlas, The Cancer Genome Atlas, Gene Expression Omnibus, Rembrandt, and Gravendeel databases. Author used Kaplan-Meier statistics and receiver operating characteristic (ROC) curves to analyze the prognostic value of BIRC5 in LGG. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontol. (GO) enrichment terms were also explored to identify functional roles of BIRC5. The Tumor Immune Estimation Resource (TIMER) and Tumor Immune System Interaction (TISIDB) databases were used to examine the correlation between BIRC5 expression and immune cell infiltration in LGG. The Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Therapeutics Response Portal (CTRP) databases were used to examine the potential drugs targeting BIRC5. Author used transwell and wound healing assays to determine the biol. functions of BIRC5 in glioma cell migration. Author results demonstrated that BIRC5 was highly expressed in LGG and the expression level correlated with tumor grade, prognosis, histol. subtype, isocitrate dehydrogenase 1 (IDH1) mutation, 1p/19q chromosomal co-deletion, chemotherapy status, and O[6]-methylguanine-DNA methyltransferase (MGMT) promoter methylation status. GO and KEGG anal. showed that BIRC5 is primarily involved in cell proliferation and immune response-related signaling pathways. Author also found that BIRC5 was significantly correlated with m6A modification and diverse drug sensitivity. TIMER and TISIDB database anal. showed that BIRC5 expression is associated with infiltration of diverse immune cells and immune modulation in LGG. BIRC5 knockdown inhibited LGG cell migration. Collectively, author results demonstrate that BIRC5 is correlated with cell migration and immune infiltration in LGG and may be a useful prognostic biomarker. This study involved multiple reactions and reactants, such as Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0Related Products of 1373423-53-0).
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Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia