Application In Synthesis of 5-Bromo-4,6-dihydroxypyrimidineOn November 1, 1989 ,《Inhibition of uridine phosphorylase from Giardia lamblia by pyrimidine analogs》 appeared in Biochemical Pharmacology. The author of the article were Jimenez, Barbara M.; Kranz, Peter; Lee, Choy Soong; Gero, Annette M.; O’Sullivan, William J.. The article conveys some information:
Fifty-six pyrimidine analogs were tested as possible inhibitors of uridine phosphorylase from G. lamblia. Values of Ki were determined for eight of these which demonstrated an inhibition >60% under the standard conditions of uridine at 1 mM (approx. 1.5 times the Km) and inhibitor at 1 mM. All were competitive with respect to uridine. The most effective inhibitors were uracil analogs substituted at the C-5 position with electron-withdrawing groups (nitro groups or halogens). The inhibitory effect at the 5-position appeared to be further enhanced by substitution at the C-6 position with electron-releasing groups. The order of effectiveness as inhibitors was 6-methyl-5-nitrouracil > 6-amino-5-nitrouracil > 5-benzylacyclouridine > 5-nitrouracil > 5-fluorouracil > 5-bromouracil > 6-benzyl-2-thiouracil > 1,3-dimethyluracil, with Ki values of 10, 12, 44, 56, 119, 230, 190 and >1000 μM, resp. The compounds were also effective inhibitors of the thymidine phosphorylase activity of the enzyme. The results are discussed in relation to the use of these pyrimidine analogs to treat G. lamblia infections. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Application In Synthesis of 5-Bromo-4,6-dihydroxypyrimidine)
5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 5-Bromo-4,6-dihydroxypyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia