The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Application of C4H3ClN2.
Jin, Ming Yu;Zhen, Qianqian;Xiao, Dengmengfei;Tao, Guanyu;Xing, Xiangyou;Yu, Peiyuan;Xu, Chen research published ã?Engineered non-covalent Ï interactions as key elements for chiral recognitionã? the research content is summarized as follows. Described here was a well-engineered catalytic system into which non-covalent Ï interactions are directly incorporated. Enabled by a lone pair-Ï interaction and a Ï-Ï stacking interaction operating collectively, efficient chiral recognition was successfully achieved in the long-pursued dihydroxylation-based kinetic resolution D. functional theory calculations shed light on the crucial role played by the lone pair-Ï interaction between the carbonyl oxygen of the cinchona alkaloid ligand and the electron-deficient phthalazine Ï moiety of the substrate in the stereoselectivity-determining transition states. This discovery serves as a proof-of-principle example showing how the weak non-covalent Ï interactions, if ingeniously designed, could be a powerful guide in attaining highly enantioselective catalysis.
Application of C4H3ClN2, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia