Jirku, V.; Vorlova, V.; Skoda, J. published the artcile< Inhibitory effect of 5-bromo-6-azauracil on growth and cell division of Saccharomyces cerevisiae>, Safety of 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione, the main research area is bromoazauracil Saccharomyces growth cell division.
The approx. min. concentration of 5-bromo-6-azauracil (I) [4956-05-2] causing significant inhibition of growth and cell division of S. cerevisiae was 8 mM. Higher concentrations had no greater inhibitory effect. Between the addition of I and the onset of its effect, there was always a delay of 120 min. The effect of I was reversed by thymine [65-71-4], cytosine [71-30-7], uracil [66-22-8], or 5-bromouracil [51-20-7]. 6-Azauracil had no effect. Evidently, I stimulates a rapid lytic process; the delay in the initiation of this process does not eliminate the possibility that cell lysis is directly or indirectly induced by a derivative or a breakdown product of I.
Experientia published new progress about Cell division. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Safety of 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia