Discovery and SAR studies of novel 2-anilinopyrimidine-based selective inhibitors against triple-negative breast cancer cell line MDA-MB-468 was written by Jo, Jeyun;Kim, Sou Hyun;Kim, Heegyu;Jeong, Myeonggyo;Kwak, Jae-Hwan;Taek Han, Young;Jeong, Jee-Yeong;Jung, Young-Suk;Yun, Hwayoung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Computed Properties of C8H10ClN3O This article mentions the following:
Triple-neg. breast cancers (TNBCs) are characterized as an invasive and intractable subtype of breast cancers. Overexpression of epidermal growth factor receptor (EGFR) has been considered to be an important target for TNBC therapy, but efficacies of EGFR inhibitors in clin. trials are elusive. In this study, novel series of 2-anilinopyrimidines were synthesized in an effort to identify selective inhibitors against an EGFR-overexpressing TNBC cell line. Biol. evaluation demonstrated that compounds I and II, with a 4-methylpiperidine group and a high ClogP value, exhibited good potency and selectivity for the TNBC cell line. This study has provided evidence to support further development of 2-anilinopyrimidine-based TNBC selective inhibitors and investigation of the targets of compounds I and II. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Computed Properties of C8H10ClN3O).
4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Computed Properties of C8H10ClN3O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia