In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Jo, Jeyun; Kim, Heegyu; Oh, Ji Youn; Kim, Soyeong; Park, Yeong Hye; Choi, Hyeonjin; Jeong, Jee-Yeong; Jung, Young-Suk; Yun, Hwayoung. Reference of 2,4-Dichloropyrimidine. The article was titled 《SAR Optimization studies on a novel series of 2-anilinopyrimidines as selective inhibitors against triple-negative breast cancer cell line MDA-MB-468》. The information in the text is summarized as follows:
Two series of 2-anilinopyrimidines I [R1 = pyrrol-1-yl, indol-1-yl, 4-Me-piperidin-1-yl; R2 = NMe2, morpholin-4-yl, thiomorpholin-4-yl, piperidin-1-yl] and II [R3 = methoxy, cyclohexyl; R4 = indol-1-yl, pyrrolidin-1-yl, 4-Cl-piperidin-1-yl, etc.] as a selective inhibitors of the basal-like TNBC cell line MDA-MB-468 were reported. An extensive anal. of structure-activity relationships of the analogs I and II revealed that aminoalkyl groups at the end of the Pr chain are amenable to modification. Compound II [R3 = cyclohexyl; R4 = 4-Cl-piperidin-1-yl] was found to be the most potent and selective and was about three times more potent and selective than I [R1 = 4-Me-piperidin-1-yl; R2 = piperidin-1-yl] was against the TNBC cells. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloropyrimidine(cas: 3934-20-1Reference of 2,4-Dichloropyrimidine)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Reference of 2,4-Dichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia