Johnson, Treat B. et al. published their research in Journal of the American Chemical Society in 1913 | CAS: 39083-15-3

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 39083-15-3

Pyrimidines. LXIV. Synthesis of 4-Methyl-5-ethyleytosine was written by Johnson, Treat B.;Bailey, George C.. And the article was included in Journal of the American Chemical Society in 1913.Application of 39083-15-3 The following contents are mentioned in the article:

2-Thio-4-methyl-5-ethyl-6-oxypyrimidine, from CS(NH2)2, AcCHEtCO2Et and Na in alc. 3-4 hrs. on the H2O bath, prisms, m. 212° (yield, 60%); its Na. salt in alc. gives with PhCH2Cl the 2-benzyltnercapto derivative, blocks, m. 160°; 2-ethylmercapto derivative, m. 138°, converted by PCl6 at 100° after 10-12 hrs. into 2-ethylmercapto-4-methyl-5-ethyl-6-chloropyrimidine, b23-1 177-80°, and by PhNH2 in hot alc. into 2-anilino-4-methyl-5-ethyl-6-oxypyrimidine, m. 195°, while alc. NH3, 3 hrs. at 150-60, instead of PhNH2 gives the 2-amino compound, Minute Prisms, m. 281-20 (decompose); hydrobromide, needles, m. 160-75°, depending on the rate of heating; hydrochloride, apparently seps. with 1 H2O, shrivels 80°, m. 11.5°. 2-Ethylmercapto-4-methyl-5-etlzyl-6-aminopyrimidine, from the above 6-Cl compound and alc. NH3 at 140-50°, stout blocks, m. 89-91°, hydrolyzed by b. concentrate HCl to the hydrochloride, powder, decompose 125°, of 2-oxy-4-methyl-5-ethyl-6-aminopyrimidine (methylethylcylosine), blocks or rectangular prisms, m. 295° (decompose); hydrobromide, blocks, dedomp. about 260°. 4-Methyl-5-ethyluracil is obtained quant. by b. 2-ethylmereapto-4-methyl-5-ethyl-6-oxypyrimidine with 2 parts of ClCH2CO2H in H2O. 2-Diphenylmethylmercapto-4-methyl-6-oxypyrimidine, from Ph2CHBr, 2-thio-4-methyluracil and Na in alc., m. 214. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Application of 39083-15-3).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 39083-15-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia