On December 31, 2017, Kabal’nova, Natalia N.; Grabovskiy, Stanislav A.; Andriayshina, Nadezhda M.; Egorov, Vladislav I.; Valiullin, Lenar R.; Nabatov, Alexey A.; Raginov, Ivan S.; Murinov, Yurii I. published an article.Related Products of 626-48-2 The title of the article was The Impact of 5-Substituted Uracil Derivatives on Immortalized Embryo Lung Cells. And the article contained the following:
Background: Pyrimidine-based drugs stimulate tissue regeneration and immunity, two components that need to be improved in a number of respiratory diseases of different etiol. (e.g. influenza and asthma). In the present study we investigated relationships between the character of substitutions in the uracil structure and the impact of the resp. uracil derivatives on the immortalized lung cells. Methods: The level of cell proliferation, maximum tolerated dose and toxic effect of 5-substituted uracil derivatives (12 compounds) were studied on the immortalized lung epithelial cells and compared with the ones of 6-methyluracil. Results: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil had the lowest cytotoxicity among the studied compounds Their maximal tolerated dosage values were 5 times higher whereas the proliferation index was increased by 25% and 75%, resp., compared to 6-methyluracil, known for its pos. effects on cell regeneration. Conclusion: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil have the best perspectives for further studies on their biol. effects. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Related Products of 626-48-2
The Article related to uracil derivative immortalize embryo lung cell, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Related Products of 626-48-2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia