Kabbaj, Youssef; Lazrek, Hassan Bihi; Barascut, Jean Louis; Imbach, Jean Louis published the artcile< Synthesis and biological activity of some unsaturated 6-aza-uracil acyclo-nucleosides>, Category: pyrimidines, the main research area is HIV antiviral acyclic nucleoside preparation human alkylation azauracil condensation.
A useful route is described for obtaining Z and E unsaturated alkylating agents, e.g. AcOCH2CH:CHCH2Br. Coupling 6-aza-uracil I (X = H, Br, R = H) with unsaturated alkylating agent followed by the deprotection with acid resin gave acyclo-nucleosides, e.g. (E and Z)-I (X = H, Br; R = Ch2CH:CHCH2OH), in good overall yields. Unsaturated acyclo-nucleosides phosphonates, e.g. II (X = H, Br), were prepared using potassium carbonate as base and 4-bromo-but-2-enyl di-Et phosphonate as the alkylating agent. The introduction of a propargyl group at the N-3 position of acyclo-nucleosides was achieved using potassium carbonate in DMF. Title 6-aza-uracil acyclo-nucleosides were tested for their in vitro antiviral activity. II (X = H, Br) showed activity at 7 μg/mL, but they were also very toxic at this concentration
Nucleosides, Nucleotides & Nucleic Acids published new progress about Acyclonucleosides Role: BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Category: pyrimidines.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia