Symmetry and polar-π effects on the dynamics of enshrouded aryl-alkyne molecular rotors was written by Karim, Arif R.;Linden, Anthony;Baldridge, Kim K.;Siegel, Jay S.. And the article was included in Chemical Science in 2010.Synthetic Route of C6H4N2 This article mentions the following:
The central ring of a 1,4-bis(arylethynyl)arene (ditolan) can be viewed as a mol. rotor with an extremely low barrier to rotation in the gas phase or solution The torsional energy profile of that ring is dependent on the relative conformation of the end capping arenes. When the capping arenes are sterically bulky m-terphenyl units, it is possible to rationalize the conformational dynamics of the central ring by a factorization anal., involving perturbation of the basic torsional energy profile by polar-π, and dispersion interactions between the flanking rings of the cap and the central ring of the ditolan. The symmetry of the construct can modulate the effect of these interactions. These principles apply to the design of materials in which a steric shroud excludes packing distortions. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Synthetic Route of C6H4N2).
2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C6H4N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia