Karimian, Azam; Karimi, Zahra published the artcile< Synthesis of A Novel Heterocyclic System of 3,8-Disubstituted-5H-Pyrimido[5',4':5,6][1,4]Thiazino[3,2-e][1,2,4]Triazine>, COA of Formula: C3H2BrN3O2, the main research area is chloro amino pyrimidothiazinotriazine preparation secondary amine nucleophilic substitution; pyrimidothiazinotriazinediyl diamine preparation.
The new compounds 6-methyl-8-morpholino-2H-pyrimido[5′,4′:5,6][1,4]thiazino[3,2e][1,2,4]triazin-3(5H)-one and 6-methyl-8-(piperidin-1-yl)-2H-pyrimido[5′,4′:5,6][1,4]thiazino[3,2-e][1,2,4]triazin-3(5H)-one were obtained from cyclocondensation of 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione with appropriate 5-amino-6-methylpyrimidine-4-thiol in DMF and in the presence of potassium carbonate under reflux. Reaction of compounds with phosphorous oxychloride gave 4-(3-chloro-6-methyl-5H-pyrimido[5′,4′:5,6][1,4]thiazino[3,2-e][1,2,4]triazin-8-yl)morpholine and 3-chloro-6-methyl-8-(piperidin-1-yl)-5H-pyrimido[5′,4′:5,6][1,4]thiazino[3,2-e][1,2,4]triazine. Nucleophilic substitution of chlorine atom of compounds with typical secondary amines in DMF and K2CO3 produced the new derivatives of the 3,8-disubstituted-5H-pyrimido[5′,4′:5,6][1,4]thiazino[3,2-e][1,2,4]triazine ring systems . All the synthesized products were characterized and confirmed by their spectroscopic and microanal. data.
Polycyclic Aromatic Compounds published new progress about Fused heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, COA of Formula: C3H2BrN3O2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia