The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. COA of Formula: C4H5N3.
Kaur, Manpreet;Singh, Rahul;Patil, Madhuri T.;Kumar, Kushvinder;Sahoo, Subash Chandra;Singh, Kamal Nain;Chaudhari, Vinod D.;Salunke, Deepak B. research published 《 Microwave-assisted Groebke-Blackburn-Bienayme multicomponent reaction to synthesize imidazo fused heterocycles via in-situ generated isocyanides from N-formylamines: An undergraduate organic laboratory experiment》, the research content is summarized as follows. A one-pot methodol. was developed for the direct conversion of N-formylamine, 2-amino pyridine, and aldehyde into 2,3-substituted imidazo[1,2-a]pyridine heterocycles using I2-PPh3-Et3N reagent system under microwave irradiation During the reaction, I2-PPh3-Et3N converts N-formylamine into isocyanide, which in the presence of in-situ generated hydrogen iodide (HI) undergoes Groebke-Balckburn-Bienayme (GBB) multicomponent reaction with aldehyde and 2-aminopyridine. The in-situ generated HI eliminates the need for an external catalyst for the GBB reaction. The developed process incorporates the use of readily accessible and cheap reagents and also avoid a sep. step for the synthesis of isocyanides having disagreeable odor. Fourteen different GBB based heterocycles was synthesized to demonstrate the feasibility of the optimized protocol. The preparation of N-formylamines utilized in the synthesis wass also elaborated and the overall process was optimized to be suitable for a typical undergraduate organic laboratory experiment One of the final products was characterized using FT-IR, 1H NMR, 13C NMR, DEPT, COSY, HSQC, HRMS, and single-crystal X-ray diffraction. Overall, the experiment will be useful in the organic chem. curriculum to teach about multicomponent reactions, the importance of isocyanides in organic synthesis, formylation of amines, application of microwave irradiation in organic synthesis, and structural elucidation of small organic mols.
COA of Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia