A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity was written by Kayathi, Narendra Babu;Panga, Siva Sankar;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of the Iranian Chemical Society in 2021.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:
A library of benzazolyl pyrimidinyl carbamothioates I [X = NH, S, O; R = H, Me, Cl, etc.] were prepared by the reaction of benzazolyl carbonothioates with pyrimidinyl-2-amine in the presence of an ionic liquid- 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) under ultrasonication at a frequency of 35 kHz and tested for antimicrobial activity. Compounds I [X = NH, S; R = Cl, O2N] displayed prominent antibacterial activity against Bacillus subtilis, while compounds I [X = NH, S; R = O2N] showed excellent antifungal activity against Aspergilus niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia