Kazemnejadi, Milad; Sardarian, Ali Reza; Esmaeilpour, Mohsen published an article in 2019, the title of the article was Introduction of two polyvinyl alcohol resins for efficient solid support Cu-catalyzed N-arylation of α-aminoacids with aryl halides in aqueous media.Category: pyrimidines And the article contains the following content:
In this article, two polyvinyl alc. (PVA)-based resins were prepared by crosslinking of epoxidized PVA-chains using of 4-(4-aminobenzyl)benzenamine as a crosslinker and polymerization of acrylated PVA chains in the another approach. The prepared PVA resins showed well hydrophilic and swelling properties in various organic solvents, which are used in solid-phase organic synthesis (SPOS). Swelling properties of these resins were examined in DMF, THF, water, ethanol, methanol, dichloromethane, and dioxane. Furthermore, the both resins were characterized by FTIR and 1H-NMR and their properties such as epoxy equivalent weight (EEW) of epoxidized PVA and d. of the resins were determined by anal. methods. Then, α-amino acids such as L-aspartic acid, L-leucine, L-alanine, L-serine, L-valine, L-threonine, and L-tyrosine were immobilized on both resins through esterification reaction between these α-amino acids with the present hydroxyl groups on PVA resins, to carry out their solid-phase N-arylation reaction in the presence of CuI as a catalyst in milder and greener conditions than free resin protocols. Hydrolysis of the corresponding N-arylated α-amino acids immobilized on the resins gave the N-arylated α-amino acids in high to excellent yields. © 2019 Wiley Periodicals, Inc.J. Appl. Polym. Sci. 2019, 136, 47597. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Category: pyrimidines
The Article related to amino acid arylation solid phase arylhalide green chem swelling, solid support recycling copper arylation polyvinyl alc resin hydrolysis, arylation reaction mechanism copper catalyst, aryl halide cross coupling reaction amino acid copper catalyst and other aspects.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia