《Design, synthesis, and anticancer evaluation of acetamide and hydrazine analogues of pyrimidine》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Khazir, Jabeena; Mir, Bilal Ahmad; Chashoo, Gousia; Maqbool, Tariq; Riley, Darren; Pilcher, Lynne. Product Details of 1193-21-1 The article mentions the following:
A library of acetamide I [R = 2-hydroxyethylamino, 1-pyrrolidinyl, N-morpholinyl, etc.] and hydrazine II [R1 = 1-pyrrolidinyl, 1-piperidinyl, N-morpholinyl, 4-propanoyl-1-piperidyl; R2 = H, 2-Br, 3,4-di-MeO, etc.] analogs were generated on the pyrimidine ring through a multistep reaction starting from 5-nitro-pyrimidine-4,6-diol and pyrimidine-4,6-diol, resp. The synthesized analogs I and II were screened for in-vitro cytotoxic activity against various human cancer cell lines like HCT-1 and HT-15 (colon), MCF-7(breast), PC-3 (prostrate), SF268 (CNS) using MTT method. From the bioassay results, it was observed that even though many of the synthesized derivatives I and II exhibited a good potency against various screened cancer cell lines, compound I [R = 1-piperidinyl] showed potent anticancer activity on all the tested cancer cell lines with IC50 value of 0.36μM on CNS cell line and 1.6μM on HT-21 cell line, and compound II [R1 = N-morpholinyl, R2 = 2-OH] showed potent activity against three tested cancer cell lines with IC50 value of 0.76μM on HT-29 cell line, 2.6μM on HCT-15 and 3.2μM on MCF-7 cell line. After reading the article, we found that the author used 4,6-Dichloropyrimidine(cas: 1193-21-1Product Details of 1193-21-1)
4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Product Details of 1193-21-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia