Substrate/inhibitor specificities of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) was written by Kierdaszuk, Borys; Krawiec, Krzysztof; Kazimierezuk, Zygmunt; Jacobsson, Ulla; Johansson, Nils G.; Munch-Petersen, Birgitte; Eriksson, Staffan; Shugar, David. And the article was included in Advances in Experimental Medicine and Biology in 1998.Reference of 56632-83-8 The following contents are mentioned in the article:
Substrate/inhibitor specificities of nucleoside analogs with modified sugar moieties towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined Substrate activities of cytosine nucleosides vs. dCK were as follows: 2′-fluoro-dC > 2′-O-methyl-C > araC > 2′-fluoro-2′-deoxy-araC > 3′-O-methyl-dC = 3′-fluoro-2′,3′-ddC > cytosine β-L-riboside > 2′,3′-ddC > C= 1-(4-hydroxy-1,2-butadienyl)-cytosine (cytallene) = 2′-azido-dC. Modified purine nucleosides were only feeble substrates: ara-A > 2′-fluoro-2′-3′-dideoxy-ara-A = 2′-O-methyl-A. With TK1 and TK2, similar sugar-modified analogs of dU and dT were feeble substrates. Surprisingly α-dT was a relatively good substrate, as well some β-L-ribonucleosides. Several 5′-substituted analogs of dC were good non-substrate inhibitors of dCK and, to a lesser extent, of TK2. The overall data are relevant to the role of these enzymes in “”activation”” (by phosphorylation) of nucleoside analogs with antiviral and antitumor activities. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Reference of 56632-83-8
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8