Klumpp, Douglas A. published the artcileElectrophilic activation of acetyl-substituted heteroaromatic compounds, Computed Properties of 66373-25-9, the main research area is electrophilic activation condensation benzene heteroaromatic compound; superacid mediated condensation heteroaromatic methyl ketone benzene.
The chem. of acetyl-substituted pyridines, thiazoles, quinoline, isoquinolines, and pyrazine, e.g., thiazole I, has been studied. These heteroarenes condense with benzene in good yields (74-96%) in the Bronsted superacid, CF3SO3H (triflic acid). Thus, reaction of I gave diphenylthiazole II in 91% yield. In these acid-catalyzed hydroxyalkylation reactions, the heteroarene compounds are significantly more reactive than acetophenone. It is proposed that the heteroarene compounds readily form dicationic electrophiles in triflic acid.
Journal of Organic Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Computed Properties of 66373-25-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia