Category: pyrimidinesOn October 15, 2010 ,《One-Pot Etherification of Purine Nucleosides and Pyrimidines》 was published in Organic Letters. The article was written by Kokatla, Hari Prasad; Lakshman, Mahesh K.. The article contains the following contents:
A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and pyrimidinones is described. Exposure of the heterocycle to 1H-benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and Cs2CO3 produces a reactive intermediate, which is converted to the desired ether by subsequent addition of an appropriate alc. or phenol and Cs2CO3. Although rapid formation of HMPA from BOP can occur in the presence of an alc. and base, as demonstrated by the reaction with methanol, under appropriate conditions these heteroaryl ethers can be efficiently synthesized. After reading the article, we found that the author used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Category: pyrimidines)
2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia