Prabhakar, Virupakshi; Kondra, Sudhakar Babu; Maddula, Srinivasula Reddy; Parandhama, G.; Latha, J. published the artcile< Synthesis, structural elucidation of novel thieno [2,3-d] pyrimidine core unit containing 1,2,4-triazoles and thiophenes as potent antimicrobial activity>, Name: 2,4-Dichlorothieno[2,3-d]pyrimidine, the main research area is thiophenylboronic acid chloro arylthienotriazolopyrimidine Suzuki coupling; thiophenyl arylthienotriazolopyrimidine preparation antibacterial antifungal activity SAR.
Several new thieno[2,3-d]pyrimidine derivatives 3-substituted phenyl-5-(thiophen-2-yl)thieno[3,2-e] [1,2,4]triazolo[4,3-c]pyrimidines I [R = Ph, 3-pyridyl, 1H-indol-2-yl, etc.] were synthesized starting from thieno[2,3-d]pyrimidine-2,4-diol. The characterization of the newly synthesized compounds I was established by IR, 1H NMR, 13C NMR and mass spectral anal. The final compounds I were screened for their antibacterial activity against Bacillus subtilis and Staphylococcus aureus from Gram pos. group of bacteria and Escherichia coli and Klebsiella pneumonia from Gram neg. group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Antibacterial and antifungal activities were evaluated and compared with the standard drugs. From antibacterial and antifungal activity screening results, it was observed that compounds I [R = 3-pyridyl, 1H-indol-2-yl, 4-F3CC6H5] possessed good activity.
Organic Chemistry: Current Research published new progress about Antibacterial agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Name: 2,4-Dichlorothieno[2,3-d]pyrimidine.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia