On October 5, 2018, Kozanecka-Okupnik, Weronika; Jasiewicz, Beata; Pospieszny, Tomasz; Jastrzab, Renata; Skrobanska, Monika; Mrowczynska, Lucyna published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Spectroscopy, molecular modeling and anti-oxidant activity studies on novel conjugates containing indole and uracil moiety. And the article contained the following:
Herein we describe our results on the synthesis and mol. modeling of new conjugates containing indole and uracil moiety. This group of compounds was synthesized by the reaction of indole alkaloid – gramine with appropriate uracil (uracil, 2-thiouracil, 6-methyl-2-thiouracil, thymine, 6-methyluracil and barbituric acid) using DMF as solvent. The structures of all products were confirmed by spectroscopic (1H NMR, 13C NMR, and FT-IR) anal., mass spectrometry (EI) and PM5 semiempirical methods. Moreover the protonation constants for studied compounds were determined The obtained conjugates were screened in vitro for antioxidant and haemolytic activities, and for the protective effects against 2,2′-azobis (2-methylpropionamidine) dihydrochloride (AAPH)-induced oxidative haemolysis of human erythrocytes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to oxidant conjugate indole alkaloid uracil preparation, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia