The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 4595-59-9.
Kralova, Veronika;Soural, Miroslav;Horak, Radim;Hradil, Pavel research published 《 Convenient Synthesis of Furo[3,2-b]quinolin-4(1H)-ones》, the research content is summarized as follows. The simple synthesis of furo[3,2-b]quinolin-4(1H)-ones I (R = H, 4-methoxyphenyl, thiophen-2-yl, etc.) from readily available 4-ethynyl-[1,3]dioxolo[4,5-c]quinolone as the key starting material was reported. After Sonogashira (hetero)arylation, formation of the furoquinoline scaffold I was accomplished using methanesulfonic acid and metal-free conditions. Although the cyclization was affected by the substitution of reaction intermediates II, the method allowed the preparation of derivatives varying at the C3-position.
4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Quality Control of 4595-59-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia