Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Product Details of C4H5N3.
Kumar, Gulshan;Das, Chinmay;Acharya, Ayan;Bhal, Subhasmita;Joshi, Mayank;Kundu, Chanakya Nath;Choudhury, Angshuman Roy;Guchhait, Sankar K. research published 《 Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents》, the research content is summarized as follows. An organocatalyzed umpolung chem. based method was established for mol.-diversity feasible synthesis of title class of chemotypes i.e. (Z)-2-Arylideneimidazo[1,2-a]pyridinones I [R1 = H, 6-OH, 7-Me, etc.; R2 = H, 4-Cl, 4-OMe, etc.] and (Z)-2-arylidenebenzo[d]imidazo[2,1-b]thiazol-3-ones such as II [R1 = H, 5-Me, 5-OH, etc.; R2 = H, 4-Cl, 4-OMe, etc.]. The analogs I showed characteristic anticancer activities with efficiency more than an anticancer drug. The compounds II [R1 = 5-OMe, R2 = H] and II [R1 = 5-OH, R2 = 4-Cl] showed enhanced apoptosis by arresting the cells in the S phase and up/down-regulation of various apoptotic proteins. The compounds’ significant effect in up/down-regulation of various apoptotic proteins, an apoptosis cascade, and the inhibition of topoisomerases-mediated DNA relaxation process was identified. The anal. of the structure-activity relationship, interference with biol. events and the drug-likeness physicochem. properties of the compounds I and II in the acceptable window indicated distinctive medicinal mol.-to-properties of the investigated chemotypes.
109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Product Details of C4H5N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia