La Colla, Paolo; Marcialis, Maria A.; Flore, Ornella; Sau, Mario; Garzia, Aldo; Loddo, Bernardo published the artcile< Specific inhibition of virus multiplication by bichlorinated pyrimidines>, COA of Formula: C5H4Cl2N2O, the main research area is antiviral dichloro pyrimidine derivative; viricidal dichloropyrimidine derivative.
None of the 13 nonchlorinated or monochlorinated pyrimidines tested had any inhibitory effect on polio 1, vaccinia, and herpes simplex viruses, but all 8 dichloro derivatives inhibited growth of all 3 viruses, with 2-amino-4,6-dichloropyrimidine (I) [56-05-3] being the most active. 2-Mercaptoethanol enhanced the antiviral effect of the dichloropyrimidines. The compounds also inhibited coxsackie B1 virus, but had no effect on vesicular stomatitis or Newcastle disease viruses. Results from the effect of protein and RNA precursors on the antipolio action of I and from the effects of I on poliovirus synthesis and organization are also given. The mechanism of action of I and the structure-activity relation for the dichloropyrimidines are discussed.
Annals of the New York Academy of Sciences published new progress about Antiviral agents. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, COA of Formula: C5H4Cl2N2O.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia