Synthetic Route of C11H8N2O4On May 1, 2018 ,《Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively “”Freeze”” the pre-translocated complex during the polymerization catalytic cycle》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Lacbay, Cyrus M.; Menni, Michael; Bernatchez, Jean A.; Gotte, Matthias; Tsantrizos, Youla S.. The article conveys some information:
Reverse transcriptase (RT) is responsible for replicating the HIV-1 genome and is a validated therapeutic target for the treatment of HIV infections. During each cycle of the RT-catalyzed DNA polymerization process, inorganic pyrophosphate is released as the byproduct of nucleotide incorporation. Small mols. were identified that act as bioisosteres of pyrophosphate and can selectively freeze the catalytic cycle of HIV-1 RT at the pre-translocated stage of the DNA- or RNA-template-primer-enzyme complex. In the experiment, the researchers used 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2Synthetic Route of C11H8N2O4)
5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Synthetic Route of C11H8N2O4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia