Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A. published the artcile< Regioselective Synthesis of 3-Aminoimidazo[1,2-a]pyrimidines with Triflic Anhydride>, Electric Literature of 89793-12-4, the main research area is regioselective synthesis aminoimidazopyrimidine cyclization pyrimidine amide triflic anhydride pyridine.
The regioselective synthesis of 3-aminoimidazo[1,2- a]pyrimidines via triflic anhydride mediated amide activation and intramol. cyclization is reported. The nature of the added pyridine base allows access to both regioisomers from a simple common precursor [e.g., treatment of pyrimidine amide I with Tf2O and pyridine bases yielded II + III (yield ratios 8:45 % using 2,6-difluoropyridine and 83:9 % using 2-fluoropyridine)]. The method tolerates a range of functional groups and provides access to novel heterocyclic scaffolds.
Synthesis published new progress about Cyclization catalysts (regioselective). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Electric Literature of 89793-12-4.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia