Lee, Jinho published the artcile3,5-Bis(aminopyrimidinyl)indole Derivatives: Synthesis and Evaluation of Pim Kinase Inhibitory Activities, Quality Control of 56-05-3, the publication is Bulletin of the Korean Chemical Society (2014), 35(7), 2123-2129, database is CAplus.
A novel series of 3,5-bis(aminopyrimidinyl)indole derivatives I (R = (CH3)2N(CH2)2O, cyclopentyloxy, Me piperazinyl, etc.) were synthesized and evaluated against Pim kinases, meridianin C was chosen as a hit structure and its substituent was modified to discover potent and selective pan-pim kinase inhibitors. Substitution at C-5-position by 2-amino-pyrimidine having hydrophilic aminoalkyl chain improved the potency were described. SAR o f substituents at C-4 position of 2-amino-pyrimidine suggested that aminoalkyl moiety, with the adequate chain length and substituent, could provide compound with the high potency and selectivity. This study suggests the 3,5-bis(aminopyrimidinyl)indole moiety is a very interesting scaffold, which can be further optimized for more potent inhibitors of pim kinases.
Bulletin of the Korean Chemical Society published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Quality Control of 56-05-3.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia