Li, Bo et al. published their research in Tetrahedron Letters in 2020 | CAS: 257280-25-4

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C10H7BrN2O

Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination was written by Li, Bo;Etheve-Quelquejeu, Melanie;Yen-Pon, Expedite;Garbay, Christiane;Chen, Huixiong. And the article was included in Tetrahedron Letters in 2020.Formula: C10H7BrN2O This article mentions the following:

Various 2,5-disubstituted pyrimidine derivatives I (R = 4-cyanophenyl, 3-tert-butyl-1-methyl-1H-pyrazol-5-yl, 4-[ethoxy(oxo)methane]phenyl, etc.; R1 = H; RR1 = -(CH2)2O(CH2)2-, -(CH2)2CH(N-(CH2)4-)(CH2)2-; R2 = H, Ph, dimethylaminyl, 4-cyclohexylpiperazin-1-yl, etc.) were synthesized under microwave irradiation via Buchwald-Hartwig amination. This concise approach provides interesting scaffolds in good to high yields and with large functional group compatibility. These novel chem. entities could be used as building blocks in drug design. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4Formula: C10H7BrN2O).

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C10H7BrN2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia