《Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068》 was published in Organic Process Research & Development in 2020. These research results belong to Li, Chaomin; Franklin, Lloyd; Chen, Robbie; Mack, Tamera; Humora, Michael; Ma, Bin; Hopkins, Brian T.; Guzowski, John; Zheng, Fengmei; MacPhee, Michael; Lin, Yiqing; Ferguson, Steven; Patience, Daniel; Moniz, George A.; Kiesman, William F.; O’Brien, Erin M.. Computed Properties of C4H2Cl2N2 The article mentions the following:
Chem. process development efforts leading to multi-kilogram production of BIIB068 hemi-adipate was discussed. Process optimization has resulted in (1) removal of late transition metal from the process; (2) streamlined process with significantly improved overall yield; (3) appropriate impurity control (including potential mutagenic impurities or PMI) which enabled delivery of quality material for toxicol. studies and clin. trials. In the experiment, the researchers used many compounds, for example, 2,4-Dichloropyrimidine(cas: 3934-20-1Computed Properties of C4H2Cl2N2)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Computed Properties of C4H2Cl2N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia