Li, Jia-hui’s team published research in Pesticide Biochemistry and Physiology in 172 | CAS: 56-05-3

Pesticide Biochemistry and Physiology published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, HPLC of Formula: 56-05-3.

Li, Jia-hui published the artcileSynthesis, herbicidal activity study and molecular docking of novel pyrimidine thiourea, HPLC of Formula: 56-05-3, the publication is Pesticide Biochemistry and Physiology (2021), 104766, database is CAplus and MEDLINE.

According to the pharmacophore binding strategy and principle of bioelectronic isobaric, used the sulfonylurea bridge as the parent structure, a series of novel thiourea compounds containing aromatic-substituted pyrimidines I (R1 = OMe, Cl, N(Et)2, etc.; R2 = Me, OEt, Cl, etc.) were designed and synthesized. The preliminary herbicidal activity tests showed that some compounds had good herbicidal activity against Digitaria adscendens, Amaranthus retroflexus, especially for compound I (R1 = OMe; R2 = Cl) and compound I (R1 = R2 = Cl). The results showed that compound I (R1 = OMe; R2 = Cl) had an inhibition rate of 81.5% on the root growth of Brassica napus L. at the concentration of 100 mg L-1, and compound I (R1 = R2 = Cl) had an inhibition rate of 81% on the root growth of Digitaria adscendens at the concentration of 100 mg L-1. Compounds I (R1 = OMe; R2 = Cl) and I (R1 = R2 = Cl) had higher comparative activity on Echinochloa crus-galli than the com. herbicide bensulfuron-Me. The preliminary structure-activity relationship (SAR) was also summarized. Authors also tested the in vivo AHAS enzyme activity inhibition experiment of 14 compounds at 100 mg L-1, and the results showed that they all have inhibitory activity on the enzyme, with the highest inhibition rate reaching 44.4% (compound I (R1 = OMe; R2 = Cl)). Based on the results of mol. docking to yeast acetohydroxyacid synthase (AHAS), the possible herbicidal activity mechanism of these compounds was evaluated.

Pesticide Biochemistry and Physiology published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, HPLC of Formula: 56-05-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia