The author of 《Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies》 were Lim, Andrew S. T.; Vincent, Isabel M.; Barrett, Michael P.; Gilbert, Ian H.. And the article was published in ACS Omega in 2019. Product Details of 3764-01-0 The author mentioned the following in the article:
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chem. scaffolds and modes of action. It is also vital to design compounds with optimal physicochem. properties to permeate the bacterial cell envelope. We described an approach of combining and integrating whole cell screening and metabolomics into early antibacterial drug discovery using a library of small polar compounds Whole cell screening of a diverse library of small polar compounds against Staphylococcus aureus gave compound I. Hit expansion was carried out to determine structure-activity relationships. A selection of compounds from this series, together with other screened active compounds, was subjected to an initial metabolomics study to provide a metabolic fingerprint of the mode of action. I and its analogs have a different mode of action from some of the known antibacterial compounds tested. This early study highlighted the potential of whole cell screening using a and metabolomics in early antibacterial drug discovery, and future works will include improving potency and performing orthogonal studies to confirm the modes of action.2,4,6-Trichloropyrimidine(cas: 3764-01-0Product Details of 3764-01-0) was used in this study.
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 3764-01-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia