Epstein-Barr virus: inhibition of replication by three new drugs was written by Lin, Jung Chung; Smith, M. Carolyn; Cheng, Yung Chi; Pagano, Joseph S.. And the article was included in Science (Washington, DC, United States) on August 5,1983.Related Products of 69256-17-3 The following contents are mentioned in the article:
Acyclovir [59277-89-3], the first clin. useful drug effective against replication of Epstein-Barr virus (EBV) was without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2′-deoxyuridine (I) [69304-47-8], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (II) [69123-90-6] and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (III) [69256-17-3] were potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by acyclovir, these 3 drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 69256-17-3
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3