《On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors》 was published in Angewandte Chemie, International Edition in 2013. These research results belong to Lipshutz, Bruce H.; Isley, Nicholas A.; Fennewald, James C.; Slack, Eric D.. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine The article mentions the following:
Transition-metal-catalyzed carbon-carbon and carbon-heteroatom bond formations are among the most heavily used types of reactions in both academic and industrial settings. As important as these are to the synthetic community, such cross-couplings come with a heavy price to our environment, and sustainability. E Factors are one measure of waste created, and organic solvents, by far, are the main contributors to the high values associated, in particular, with the pharmaceutical and fine-chem. companies which utilize these reactions. An alternative to organic solvents in which cross-couplings are run can be found in the form of micellar catalysis, wherein nanoparticles composed of newly introduced designer surfactants enable the same cross-couplings, albeit in water, with most taking place at room temperature In the absence of an organic solvent as the reaction medium, organic waste and hence, E Factors, drop dramatically. After reading the article, we found that the author used 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)
4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Reference of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia