Liu, Ju; Wu, Shuang; Wang, Huan; Du, Si-Yuan; Li, Zhen; Shen, Ji-Wei; Chen, Ye; Ding, Shi published an article in 2022. The article was titled 《Novel 2,4-diarylaminopyrimidine derivatives containing pyridine moiety: design, synthesis, crystal structure and biological evaluation》, and you may find the article in Chinese Journal of Structural Chemistry.Electric Literature of C4H2Cl2N2 The information in the text is summarized as follows:
A series of 2,4-diarylaminopyrimidine derivatives I [R = H, 4-Me, 4-F, etc.] containing pyridine structure were designed and synthesized. The crystal structures of compounds I [R = 3-Cl, 4-F-3-Cl] were obtained from X-ray diffraction. The crystal structure of I [R = 3-Cl] (C25H20ClFN6O2) belongs to the monoclinic system, space group P21/c with a = 11.0500(10), b = 18.3045(17), c = 13.5646(9) Å and β = 122.806(5)°. I [R = 4-F-3-Cl] (C25H19ClF2N6O2) was of monoclinic system, space group P21/c with a = 10.9998(18), b = 18.517(3), c = 13.6355(16) Å and β = 123.315(9)°. The bioassay results showed all of the target compounds I exhibited potential antiproliferative activities against MKN-45, HT-29, A549, K562 and GIST882 cell lines. Among them, compounds I [R = H, 4-Cl, 4-F-3-Cl] exhibited remarkable inhibitory activities against GIST882, K562 and A549 cell lines with IC50 values of 0.68, 0.38 and 0.60μM, resp., which were comparable to that of the pos. control foretinib. The results came from multiple reactions, including the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Electric Literature of C4H2Cl2N2)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Electric Literature of C4H2Cl2N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia