In 2017,Organic Chemistry Frontiers included an article by Liu, Yuan; Yu, Yang; Fu, Yiwei; Liu, Yonghai; Shi, Lei; Li, Hao; Wang, Wei. Computed Properties of C8H10N2O2. The article was titled 《Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes》. The information in the text is summarized as follows:
A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes were developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramol. N-alkylation and aromatization were involved in this convergent and feasible “”one-pot”” tandem reaction to afford the annulation products in moderate to good yields. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Computed Properties of C8H10N2O2)
Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Computed Properties of C8H10N2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia